March 2013 JPGN Articles
Article #1: Thiopurine methyltransferase (TPMT) genotype testing will identify patients at risk for developing which of the following?
A - Cytomegalovirus infection
B - Leukopenia
C - Pancreatitis
D - Malignancy
E - Hepatitis
Article #1: What are the true statement(s) regarding 6-thioguanine levels (6TGN) levels?
A - Levels can predict risk for pancreatitis
B - Values of 230 -400 pmole/RBC are associated with an 85% chance of successful treatment with a thiopurine
C - These are the only way to check drug adherence
D - Levels correlate with leukopenia
E - Levels can predict risk of hepatitis
Article #1: Which is a true statement regarding thiopurine metabolite levels:
A - Most patients with an elevated 6-methylmercaptopurine (6-MMP) level, will have elevated transaminases
B - Levels should be checked prior to initiating thiopurine therapy
C - Patients on thiopurines should have 6TGN and 6MMP levels measured at least annually
D - 6TGN levels can predict the early development of lymphoma
E - Concomitant 5-Aminosalycilate therapy can enhance 6TGN levels
Article #1: Based on in vitro studies, which of the following can affect TPMT enzyme activity?
A - 5-aminosalicylic acid
B - Hyperammonemia
C - Allopurinol
D - Infliximab
E - Methotrexate
Article #1: The xanthine oxidase inhibitor, allopurinol, can be utilized in the IBD patient to maximize response by affecting the metabolism of thiopurine. This is most commonly used in the patient with
A - Elevated creatinine
B - High 6-MMP and 6-TGN levels
C - High 6-MMP and low 6-TGN levels
D - High white blood cell count
E - Low aminotransferases
Article #2: Which of the following clinical features is most predictive of EoE?
A - Heartburn/retrosternal chest pain
B - Dysphagia in an male patient with atopy
C - Elevated numbers of eosinophils in the proximal esophagus
D - History of recurrent food impaction
Article #2: Which of the following endoscopic features is most predictive of EoE?
A - Linear furrowing
B - Trachealization/multiple rings
C - White papules
D - Narrow esophagus
Article #2: Based on the current study, do peripheral blood eosinophils help predict a diagnosis of EoE?
A - True
B - False