March 2013 JPGN Articles
1 - Article #1: Thiopurine methyltransferase (TPMT) genotype testing will identify patients at risk for developing which of the following?
A   - Cytomegalovirus infection
B   - Leukopenia
C   - Pancreatitis
D   - Malignancy
E   - Hepatitis
2 - Article #1: What are the true statement(s) regarding 6-thioguanine levels (6TGN) levels?
A   - Levels can predict risk for pancreatitis
B   - Values of 230 -400 pmole/RBC are associated with an 85% chance of successful treatment with a thiopurine
C   - These are the only way to check drug adherence
D   - Levels correlate with leukopenia
E   - Levels can predict risk of hepatitis
3 - Article #1: Which is a true statement regarding thiopurine metabolite levels:
A   - Most patients with an elevated 6-methylmercaptopurine (6-MMP) level, will have elevated transaminases
B   - Levels should be checked prior to initiating thiopurine therapy
C   - Patients on thiopurines should have 6TGN and 6MMP levels measured at least annually
D   - 6TGN levels can predict the early development of lymphoma
E   - Concomitant 5-Aminosalycilate therapy can enhance 6TGN levels
4 - Article #1: Based on in vitro studies, which of the following can affect TPMT enzyme activity?
A   - 5-aminosalicylic acid
B   - Hyperammonemia
C   - Allopurinol
D   - Infliximab
E   - Methotrexate
5 - Article #1: The xanthine oxidase inhibitor, allopurinol, can be utilized in the IBD patient to maximize response by affecting the metabolism of thiopurine. This is most commonly used in the patient with
A   - Elevated creatinine
B   - High 6-MMP and 6-TGN levels
C   - High 6-MMP and low 6-TGN levels
D   - High white blood cell count
E   - Low aminotransferases
6 - Article #2: Which of the following clinical features is most predictive of EoE?
A   - Heartburn/retrosternal chest pain
B   - Dysphagia in an male patient with atopy
C   - Elevated numbers of eosinophils in the proximal esophagus
D   - History of recurrent food impaction
7 - Article #2: Which of the following endoscopic features is most predictive of EoE?
A   - Linear furrowing
B   - Trachealization/multiple rings
C   - White papules
D   - Narrow esophagus
8 - Article #2: Based on the current study, do peripheral blood eosinophils help predict a diagnosis of EoE?
A   - True
B   - False